QSAR Methods to Screen Endocrine Disruptors
نویسندگان
چکیده
منابع مشابه
Endocrine disruptors: from endocrine to metabolic disruption.
Synthetic chemicals currently used in a variety of industrial and agricultural applications are leading to widespread contamination of the environment. Even though the intended uses of pesticides, plasticizers, antimicrobials, and flame retardants are beneficial, effects on human health are a global concern. These so-called endocrine-disrupting chemicals (EDCs) can disrupt hormonal balance and ...
متن کاملEndocrine Disruptors
Law and science combine in the estimation of risks from endocrine disruptors (EDs) and actions for their regulation. For both, dose–response models are the causal link between exposure and probability (or percentage change) of adverse response. The evidence that leads to either regulations or judicial decrees is affected by uncertainty and limited knowledge, raising difficult policy issues that...
متن کاملTheoretical approach to endocrine disruptors.
Endocrine disruptors are now of scientific and public concern, because there is increasing evidence of their adverse effects on the health of an intact organism or its progeny and on changes in endocrine function. Although numerous substances have been identified as such chemicals, a huge number of chemicals remain to be tested for their endocrine disrupting capabilities. Because of the time an...
متن کاملEndocrine Disruptors and Obesity
PURPOSE OF REVIEW The purpose of this review was to summarise current evidence that some environmental chemicals may be able to interfere in the endocrine regulation of energy metabolism and adipose tissue structure. RECENT FINDINGS Recent findings demonstrate that such endocrine-disrupting chemicals, termed "obesogens", can promote adipogenesis and cause weight gain. This includes compounds ...
متن کاملEndocrine Disruptors in Endometriosis
Endometriosis is an estrogen-dependent disease, which involves the growth of endometrial tissue outside the uterine cavity, commonly in the pelvic region. The etiology of the disease is unclear, but multiple factors may contribute to its prognosis. Toxicological studies indicate that many chemicals are able to interfere with endocrine homeostasis, called endocrine disrupting chemicals (EDC) lik...
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ژورنال
عنوان ژورنال: Nuclear Receptor Research
سال: 2016
ISSN: 2314-5714,2314-5706
DOI: 10.11131/2016/101203